antiepileptic drug | TEST DIRECTORY

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antiepileptic drug

Laboratory：Hachioji

○antiepileptic drug

TEST NAME	SPECIMEN REQUIREMENT （ｍL）	CONTAINER	CAP COLOR	STORE TEMPERATURE (STABILITY)	TURNAROUND TIME (DAY)	METHODOLOGY	REFERENCE RANGE (UNIT)	BLOOD COLLECTION TIME
Carbamazepine	Serum 0.5	S7P ↓ A00			2-4	Enzyme immunoassay(EIA) EIA (Enzyme immunoassay) Enzyme immunoassay The measurement principle is the same as RIA; an antigen-antibody reaction is performed using an enzyme-labeled antigen or antibody as a labeling substance, and a chromogenic substrate is added to detect enzyme activity. How to measure.	4-12(μg/mL)	Immediately before next administration (Trough concentration)
Carbamazepine	Plasma 0.5	PH5 ↓ A00			2-4	Enzyme immunoassay(EIA) EIA (Enzyme immunoassay) Enzyme immunoassay The measurement principle is the same as RIA; an antigen-antibody reaction is performed using an enzyme-labeled antigen or antibody as a labeling substance, and a chromogenic substrate is added to detect enzyme activity. How to measure.	4-12(μg/mL)	Immediately before next administration (Trough concentration)
Clonazepam	Serum 0.3	S7P ↓ A00			3-5	LC/MS/MS LC/MS/MS (Liquid chromatography tandem mass spectrometry) Liquid chromatography tandem quadrupole mass spectrometry Liquid chromatography uses differences in affinity to decompose components of a target substance. , a method in which ions of a specific mass are further separated by mass using a mass spectrometer, dissociated and fragmented, and then these ions are detected.	20-70(ng/mL)	Immediately before next administration (Trough concentration)
Diazepam	Serum 0.5	S7P ↓ A00			3-6	HPLC HPLC (High performance liquid chromatography) High performance liquid chromatography A method of liquid chromatography that uses a liquid as a mobile phase to achieve high speed and high precision separation using a densely packed column and a high pressure pump.	Diazepam 600-1000(ng/mL)	Immediately before the next administration (Trough concentration) However, when used as an antiepileptic drug
Ethosuximide	Serum 0.5	S7P ↓ A00			2-4	Enzyme immunoassay(EIA) EIA (Enzyme immunoassay) Enzyme immunoassay The measurement principle is the same as RIA; an antigen-antibody reaction is performed using an enzyme-labeled antigen or antibody as a labeling substance, and a chromogenic substrate is added to detect enzyme activity. How to measure.	40.0-100.0(μg/mL)	Immediately before next administration (Trough concentration)
Ethosuximide	Plasma 0.5	PH5 ↓ A00			2-4	Enzyme immunoassay(EIA) EIA (Enzyme immunoassay) Enzyme immunoassay The measurement principle is the same as RIA; an antigen-antibody reaction is performed using an enzyme-labeled antigen or antibody as a labeling substance, and a chromogenic substrate is added to detect enzyme activity. How to measure.	40.0-100.0(μg/mL)	Immediately before next administration (Trough concentration)
Clobazam	Serum 0.3	S7P ↓ A00			3-5	LC/MS/MS LC/MS/MS (Liquid chromatography tandem mass spectrometry) Liquid chromatography tandem quadrupole mass spectrometry Liquid chromatography uses differences in affinity to decompose components of a target substance. , a method in which ions of a specific mass are further separated by mass using a mass spectrometer, dissociated and fragmented, and then these ions are detected.	(ng/mL)
Nitrazepam	Serum 0.3	S7P ↓ A00			3-5	LC/MS/MS LC/MS/MS (Liquid chromatography tandem mass spectrometry) Liquid chromatography tandem quadrupole mass spectrometry Liquid chromatography uses differences in affinity to decompose components of a target substance. , a method in which ions of a specific mass are further separated by mass using a mass spectrometer, dissociated and fragmented, and then these ions are detected.	20-200(ng/mL)	Immediately before the next administration (Trough concentration) However, when used as an antiepileptic drug
Phenobarbital	Serum 0.5	S7P ↓ A00			2-4	Enzyme immunoassay(EIA) EIA (Enzyme immunoassay) Enzyme immunoassay The measurement principle is the same as RIA; an antigen-antibody reaction is performed using an enzyme-labeled antigen or antibody as a labeling substance, and a chromogenic substrate is added to detect enzyme activity. How to measure.	10-40(μg/mL)	Immediately before next administration (Trough concentration)
Phenobarbital	Plasma 0.5	PH5 ↓ A00			2-4	Enzyme immunoassay(EIA) EIA (Enzyme immunoassay) Enzyme immunoassay The measurement principle is the same as RIA; an antigen-antibody reaction is performed using an enzyme-labeled antigen or antibody as a labeling substance, and a chromogenic substrate is added to detect enzyme activity. How to measure.	10-40(μg/mL)	Immediately before next administration (Trough concentration)
Phenytoin	Serum 0.5	S7P ↓ A00			2-4	Enzyme immunoassay(EIA) EIA (Enzyme immunoassay) Enzyme immunoassay The measurement principle is the same as RIA; an antigen-antibody reaction is performed using an enzyme-labeled antigen or antibody as a labeling substance, and a chromogenic substrate is added to detect enzyme activity. How to measure.	10.0-20.0(μg/mL)	Oral: Immediately before the next dose (Trough concentration) Intravenous: 2 to 4 hours after administration
Phenytoin	Plasma 0.5	PH5 ↓ A00			2-4	Enzyme immunoassay(EIA) EIA (Enzyme immunoassay) Enzyme immunoassay The measurement principle is the same as RIA; an antigen-antibody reaction is performed using an enzyme-labeled antigen or antibody as a labeling substance, and a chromogenic substrate is added to detect enzyme activity. How to measure.	10.0-20.0(μg/mL)	Oral: Immediately before the next dose (Trough concentration) Intravenous: 2 to 4 hours after administration
Primidone	Serum 0.3	S7P ↓ A00			2-4	Enzyme immunoassay(EIA) EIA (Enzyme immunoassay) Enzyme immunoassay The measurement principle is the same as RIA; an antigen-antibody reaction is performed using an enzyme-labeled antigen or antibody as a labeling substance, and a chromogenic substrate is added to detect enzyme activity. How to measure.	5.0-12.0(μg/mL)	Immediately before next administration (Trough concentration)
Primidone	Plasma 0.3	PH5 ↓ A00			2-4	Enzyme immunoassay(EIA) EIA (Enzyme immunoassay) Enzyme immunoassay The measurement principle is the same as RIA; an antigen-antibody reaction is performed using an enzyme-labeled antigen or antibody as a labeling substance, and a chromogenic substrate is added to detect enzyme activity. How to measure.	5.0-12.0(μg/mL)	Immediately before next administration (Trough concentration)
Valproate	Serum 0.5	S7P ↓ A00			2-4	Enzyme immunoassay(EIA) EIA (Enzyme immunoassay) Enzyme immunoassay The measurement principle is the same as RIA; an antigen-antibody reaction is performed using an enzyme-labeled antigen or antibody as a labeling substance, and a chromogenic substrate is added to detect enzyme activity. How to measure.	50-100(μg/mL)	Immediately before next administration (Trough concentration)
Valproate	Plasma 0.5	PH5 ↓ A00			2-4	Enzyme immunoassay(EIA) EIA (Enzyme immunoassay) Enzyme immunoassay The measurement principle is the same as RIA; an antigen-antibody reaction is performed using an enzyme-labeled antigen or antibody as a labeling substance, and a chromogenic substrate is added to detect enzyme activity. How to measure.	50-100(μg/mL)	Immediately before next administration (Trough concentration)
Trimethadione	Serum 0.5	S7P ↓ A00		（12 days）	7-13	LC-MS/MS	300-500(μg/mL)
Zonisamide	Serum 0.5	S7P ↓ A00			2-4	latex agglutination method	10-30(μg/mL)	Immediately before next administration (Trough concentration)
Gabapentin	Plasma 0.3	PH5 ↓ A00			3-5	LC/MS/MS LC/MS/MS (Liquid chromatography tandem mass spectrometry) Liquid chromatography tandem quadrupole mass spectrometry Liquid chromatography uses differences in affinity to decompose components of a target substance. , a method in which ions of a specific mass are further separated by mass using a mass spectrometer, dissociated and fragmented, and then these ions are detected.	(μg/mL)
Lamotrigine	Plasma 0.3	PH5 ↓ A00			3-5	LC/MS/MS LC/MS/MS (Liquid chromatography tandem mass spectrometry) Liquid chromatography tandem quadrupole mass spectrometry Liquid chromatography uses differences in affinity to decompose components of a target substance. , a method in which ions of a specific mass are further separated by mass using a mass spectrometer, dissociated and fragmented, and then these ions are detected.	2.5-15(μg/mL)	Immediately before next administration (Trough concentration)
Topiramate	Plasma 0.3	PH5 ↓ A00		（21 days）	3-5	LC/MS/MS LC/MS/MS (Liquid chromatography tandem mass spectrometry) Liquid chromatography tandem quadrupole mass spectrometry Liquid chromatography uses differences in affinity to decompose components of a target substance. , a method in which ions of a specific mass are further separated by mass using a mass spectrometer, dissociated and fragmented, and then these ions are detected.	5-20 (μg/mL)	Immediately before next administration (Trough concentration)
Levetiracetam	Plasma 0.3	PH5 ↓ A00		（21 days）	3-5	LC/MS/MS LC/MS/MS (Liquid chromatography tandem mass spectrometry) Liquid chromatography tandem quadrupole mass spectrometry Liquid chromatography uses differences in affinity to decompose components of a target substance. , a method in which ions of a specific mass are further separated by mass using a mass spectrometer, dissociated and fragmented, and then these ions are detected.	12-46 (μg/mL)	Immediately before next administration (Trough concentration)
Brivaracetam	Plasma 0.3	PH5 ↓ A00		（28 days）	3-9	LC/MS/MS LC/MS/MS (Liquid chromatography tandem mass spectrometry) Liquid chromatography tandem quadrupole mass spectrometry Liquid chromatography uses differences in affinity to decompose components of a target substance. , a method in which ions of a specific mass are further separated by mass using a mass spectrometer, dissociated and fragmented, and then these ions are detected.	(μg/mL)	Immediately before next administration (Trough concentration)
Stiripentol	Plasma 0.3	PH5 ↓ A00		（28 days）	5-11	LC/MS/MS LC/MS/MS (Liquid chromatography tandem mass spectrometry) Liquid chromatography tandem quadrupole mass spectrometry Liquid chromatography uses differences in affinity to decompose components of a target substance. , a method in which ions of a specific mass are further separated by mass using a mass spectrometer, dissociated and fragmented, and then these ions are detected.	(μg/mL)
Rufinamide	Plasma 0.3	PN2,PN5 ↓ A00		（28 days）	3-9	LC/MS/MS LC/MS/MS (Liquid chromatography tandem mass spectrometry) Liquid chromatography tandem quadrupole mass spectrometry Liquid chromatography uses differences in affinity to decompose components of a target substance. , a method in which ions of a specific mass are further separated by mass using a mass spectrometer, dissociated and fragmented, and then these ions are detected.	(μg/mL)
Perampanel	Plasma 0.3	PH5 ↓ A00		（28 days）	3-5	LC/MS/MS LC/MS/MS (Liquid chromatography tandem mass spectrometry) Liquid chromatography tandem quadrupole mass spectrometry Liquid chromatography uses differences in affinity to decompose components of a target substance. , a method in which ions of a specific mass are further separated by mass using a mass spectrometer, dissociated and fragmented, and then these ions are detected.	(ng/mL)
Lacosamide	Plasma 0.3	PH5 ↓ A00		（28 days）	3-5	LC/MS/MS LC/MS/MS (Liquid chromatography tandem mass spectrometry) Liquid chromatography tandem quadrupole mass spectrometry Liquid chromatography uses differences in affinity to decompose components of a target substance. , a method in which ions of a specific mass are further separated by mass using a mass spectrometer, dissociated and fragmented, and then these ions are detected.	(μg/mL)	Immediately before next administration (Trough concentration)
Acetazolamide	Serum 0.3	S7P ↓ A00			3-9	HPLC HPLC (High performance liquid chromatography) High performance liquid chromatography A method of liquid chromatography that uses a liquid as a mobile phase to achieve high speed and high precision separation using a densely packed column and a high pressure pump.	(μg/mL)
Free Phenytoin（Suspended beyond orders placed 03-31-2022）	Serum 1.0	S7P ↓ A00		（14 days）	4-10	Ultrafiltration method EIA KIMS (Kinetic Interaction of Microparticles in Solution) A method in which an antigen-antibody reaction is performed using microparticles bound to antigens or antibodies, and the turbidity of the agglutination caused by the antigen-antibody reaction is measured from the transmittance by irradiating it with light.	1.0-2.0(μg/mL)	Oral: Immediately before the next dose (Trough concentration) Intravenous: 2 to 4 hours after administration
Free valproic acid（Suspended beyond orders placed 03-31-2022）	Serum 1.0	S7P ↓ A00		（14 days）	4-10	Ultrafiltration method EIA KIMS (Kinetic Interaction of Microparticles in Solution) A method in which an antigen-antibody reaction is performed using microparticles bound to antigens or antibodies, and the turbidity of the agglutination caused by the antigen-antibody reaction is measured from the transmittance by irradiating it with light.	5.0-15.0(μg/mL)	Immediately before next administration (Trough concentration)
Zonisamide（Suspended beyond orders placed 12-01-2017）	Plasma 0.2	PH5 ↓ A00				HPLC KIMS (Kinetic Interaction of Microparticles in Solution) A method in which an antigen-antibody reaction is performed using microparticles bound to antigens or antibodies, and the turbidity of the agglutination caused by the antigen-antibody reaction is measured from the transmittance by irradiating it with light.	10-30(μg/mL)	Immediately before next administration (Trough concentration)
Zonisamide（Suspended beyond orders placed 12-01-2017）	Serum 0.2	S7P ↓ A00				HPLC KIMS (Kinetic Interaction of Microparticles in Solution) A method in which an antigen-antibody reaction is performed using microparticles bound to antigens or antibodies, and the turbidity of the agglutination caused by the antigen-antibody reaction is measured from the transmittance by irradiating it with light.	10-30(μg/mL)	Immediately before next administration (Trough concentration)

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