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circulatory drug

Laboratory：Hachioji

○circulatory drug

TEST NAME	SPECIMEN REQUIREMENT （ｍL）	CONTAINER	CAP COLOR	STORE TEMPERATURE (STABILITY)	TURNAROUND TIME (DAY)	METHODOLOGY	REFERENCE RANGE (UNIT)	BLOOD COLLECTION TIME
Digoxin	Serum 0.5	S7P ↓ A00			2-4	Enzyme immunoassay(EIA) EIA (Enzyme immunoassay) Enzyme immunoassay The measurement principle is the same as RIA; an antigen-antibody reaction is performed using an enzyme-labeled antigen or antibody as a labeling substance, and a chromogenic substrate is added to detect enzyme activity. How to measure.	Vanishing phase concentration 0.8-2.0 (ng/mL)	6 hours after administration to immediately before next administration (disappearance phase)
Amiodarone	Plasma 0.3	PH5 ↓ A00			3-5	LC/MS/MS LC/MS/MS (Liquid chromatography tandem mass spectrometry) Liquid chromatography tandem quadrupole mass spectrometry Liquid chromatography uses differences in affinity to decompose components of a target substance. , a method in which ions of a specific mass are further separated by mass using a mass spectrometer, dissociated and fragmented, and then these ions are detected.	(ng/mL)	Immediately before next administration (Trough concentration)
Bepridil	Plasma 0.3	PH5 ↓ A00		（21 days）	3-5	LC/MS/MS LC/MS/MS (Liquid chromatography tandem mass spectrometry) Liquid chromatography tandem quadrupole mass spectrometry Liquid chromatography uses differences in affinity to decompose components of a target substance. , a method in which ions of a specific mass are further separated by mass using a mass spectrometer, dissociated and fragmented, and then these ions are detected.	250-800(ng/mL)
Aprindine	Serum 0.3	S7P ↓ A00			3-5	LC/MS/MS LC/MS/MS (Liquid chromatography tandem mass spectrometry) Liquid chromatography tandem quadrupole mass spectrometry Liquid chromatography uses differences in affinity to decompose components of a target substance. , a method in which ions of a specific mass are further separated by mass using a mass spectrometer, dissociated and fragmented, and then these ions are detected.	0.25-1.25(μg/mL)	Oral: Immediately before the next dose (Trough concentration) 2 to 4 hours after administration (Peak concentration) Intravenous injection: Immediately before the next dose (Trough concentration)
Aprindine	Plasma 0.3	PH5 ↓ A00			3-5	LC/MS/MS LC/MS/MS (Liquid chromatography tandem mass spectrometry) Liquid chromatography tandem quadrupole mass spectrometry Liquid chromatography uses differences in affinity to decompose components of a target substance. , a method in which ions of a specific mass are further separated by mass using a mass spectrometer, dissociated and fragmented, and then these ions are detected.	0.25-1.25(μg/mL)	Oral: Immediately before the next dose (Trough concentration) 2 to 4 hours after administration (Peak concentration) Intravenous injection: Immediately before the next dose (Trough concentration)
Disopyramide	Serum 0.3	S7P ↓ A00			2-4	Enzyme immunoassay(EIA) EIA (Enzyme immunoassay) Enzyme immunoassay The measurement principle is the same as RIA; an antigen-antibody reaction is performed using an enzyme-labeled antigen or antibody as a labeling substance, and a chromogenic substrate is added to detect enzyme activity. How to measure.	2.0-5.0(μg/mL)	Immediately before next administration (Trough concentration)
Disopyramide	Plasma 0.3	PH5 ↓ A00			2-4	Enzyme immunoassay(EIA) EIA (Enzyme immunoassay) Enzyme immunoassay The measurement principle is the same as RIA; an antigen-antibody reaction is performed using an enzyme-labeled antigen or antibody as a labeling substance, and a chromogenic substrate is added to detect enzyme activity. How to measure.	2.0-5.0(μg/mL)	Immediately before next administration (Trough concentration)
Lidocaine	Serum 0.3	S7P ↓ A00			2-4	Enzyme immunoassay(EIA) EIA (Enzyme immunoassay) Enzyme immunoassay The measurement principle is the same as RIA; an antigen-antibody reaction is performed using an enzyme-labeled antigen or antibody as a labeling substance, and a chromogenic substrate is added to detect enzyme activity. How to measure.	1.2-5.0(μg/mL)	Intravenous infusion: 2 hours after administration Intravenous infusion: 6 to 12 hours
Mexilethine	Serum 0.3	S7P ↓ A00			3-5	LC/MS/MS LC/MS/MS (Liquid chromatography tandem mass spectrometry) Liquid chromatography tandem quadrupole mass spectrometry Liquid chromatography uses differences in affinity to decompose components of a target substance. , a method in which ions of a specific mass are further separated by mass using a mass spectrometer, dissociated and fragmented, and then these ions are detected.	0.5-2.0(μg/mL)	Oral: Immediately before the next dose (Trough concentration) Intravenous injection: As needed
Procainamide	Serum 0.4	S7P ↓ A00			2-4	Enzyme immunoassay(EIA) EIA (Enzyme immunoassay) Enzyme immunoassay The measurement principle is the same as RIA; an antigen-antibody reaction is performed using an enzyme-labeled antigen or antibody as a labeling substance, and a chromogenic substrate is added to detect enzyme activity. How to measure.	4.0-10.0(μg/mL)	Immediately before next administration (Trough concentration)
Procainamide	Plasma 0.4	PH5 ↓ A00			2-4	Enzyme immunoassay(EIA) EIA (Enzyme immunoassay) Enzyme immunoassay The measurement principle is the same as RIA; an antigen-antibody reaction is performed using an enzyme-labeled antigen or antibody as a labeling substance, and a chromogenic substrate is added to detect enzyme activity. How to measure.	4.0-10.0(μg/mL)	Immediately before next administration (Trough concentration)
Propranolol	Serum 0.3	S7P ↓ A00			Please contact us in advance.	HPLC HPLC (High performance liquid chromatography) High performance liquid chromatography A method of liquid chromatography that uses a liquid as a mobile phase to achieve high speed and high precision separation using a densely packed column and a high pressure pump.	50-100(ng/mL)	Immediately before next administration (Trough concentration)
Propranolol	Plasma 0.3	PH5 ↓ A00			Please contact us in advance.	HPLC HPLC (High performance liquid chromatography) High performance liquid chromatography A method of liquid chromatography that uses a liquid as a mobile phase to achieve high speed and high precision separation using a densely packed column and a high pressure pump.	50-100(ng/mL)	Immediately before next administration (Trough concentration)
Pirsicainide	Serum 0.3	S7P ↓ A00			3-5	LC/MS/MS LC/MS/MS (Liquid chromatography tandem mass spectrometry) Liquid chromatography tandem quadrupole mass spectrometry Liquid chromatography uses differences in affinity to decompose components of a target substance. , a method in which ions of a specific mass are further separated by mass using a mass spectrometer, dissociated and fragmented, and then these ions are detected.	0.2-0.9(μg/mL)	Immediately before next administration (Trough concentration)
Pirsicainide	Plasma 0.3	PH5 ↓ A00			3-5	LC/MS/MS LC/MS/MS (Liquid chromatography tandem mass spectrometry) Liquid chromatography tandem quadrupole mass spectrometry Liquid chromatography uses differences in affinity to decompose components of a target substance. , a method in which ions of a specific mass are further separated by mass using a mass spectrometer, dissociated and fragmented, and then these ions are detected.	0.2-0.9(μg/mL)	Immediately before next administration (Trough concentration)
Propafenone	Serum 0.3	S7P ↓ A00			3-5	LC/MS/MS LC/MS/MS (Liquid chromatography tandem mass spectrometry) Liquid chromatography tandem quadrupole mass spectrometry Liquid chromatography uses differences in affinity to decompose components of a target substance. , a method in which ions of a specific mass are further separated by mass using a mass spectrometer, dissociated and fragmented, and then these ions are detected.	(ng/mL)
Cibenzoline	Serum 0.3	S7P ↓ A00			3-5	LC/MS/MS LC/MS/MS (Liquid chromatography tandem mass spectrometry) Liquid chromatography tandem quadrupole mass spectrometry Liquid chromatography uses differences in affinity to decompose components of a target substance. , a method in which ions of a specific mass are further separated by mass using a mass spectrometer, dissociated and fragmented, and then these ions are detected.	Trough concentration 70-250(ng/mL)	Immediately before morning administration (Trough concentration)
Cibenzoline	Plasma 0.3	PH5 ↓ A00			3-5	LC/MS/MS LC/MS/MS (Liquid chromatography tandem mass spectrometry) Liquid chromatography tandem quadrupole mass spectrometry Liquid chromatography uses differences in affinity to decompose components of a target substance. , a method in which ions of a specific mass are further separated by mass using a mass spectrometer, dissociated and fragmented, and then these ions are detected.	Trough concentration 70-250(ng/mL)	Immediately before morning administration (Trough concentration)
Pirmenol	Plasma 1.3	PH5 ↓ A00			3-9	HPLC HPLC (High performance liquid chromatography) High performance liquid chromatography A method of liquid chromatography that uses a liquid as a mobile phase to achieve high speed and high precision separation using a densely packed column and a high pressure pump.	400.0 or less (ng/mL)	at any time
Quinidine	Serum 0.4	S7P ↓ A00			2-8	KIMS KIMS (Kinetic Interaction of Microparticles in Solution) A method in which an antigen-antibody reaction is performed using microparticles bound to antigens or antibodies, and the turbidity of the agglutination caused by the antigen-antibody reaction is measured from the transmittance by irradiating it with light.	2.0-6.0(μg/mL)	Immediately before next administration (Trough concentration)
Quinidine	Plasma 0.4	PH5 ↓ A00			2-8	KIMS KIMS (Kinetic Interaction of Microparticles in Solution) A method in which an antigen-antibody reaction is performed using microparticles bound to antigens or antibodies, and the turbidity of the agglutination caused by the antigen-antibody reaction is measured from the transmittance by irradiating it with light.	2.0-6.0(μg/mL)	Immediately before next administration (Trough concentration)
Flecainide	Serum 0.3	S7P ↓ A00			3-5	LC/MS/MS LC/MS/MS (Liquid chromatography tandem mass spectrometry) Liquid chromatography tandem quadrupole mass spectrometry Liquid chromatography uses differences in affinity to decompose components of a target substance. , a method in which ions of a specific mass are further separated by mass using a mass spectrometer, dissociated and fragmented, and then these ions are detected.	200-1000(ng/mL)	Immediately before next administration (Trough concentration)
Flecainide	Plasma 0.3	PH5 ↓ A00			3-5	LC/MS/MS LC/MS/MS (Liquid chromatography tandem mass spectrometry) Liquid chromatography tandem quadrupole mass spectrometry Liquid chromatography uses differences in affinity to decompose components of a target substance. , a method in which ions of a specific mass are further separated by mass using a mass spectrometer, dissociated and fragmented, and then these ions are detected.	200-1000(ng/mL)	Immediately before next administration (Trough concentration)
N-Acetylprocainamide（Suspended beyond orders placed 11-30-2017）	Serum 0.4	S7P ↓ A00			2-4	Enzyme immunoassay(EIA) EIA (Enzyme Immunoassay Assay) Enzyme immunoassay The principle of measurement is the same as that of RIA. An antigen-antibody reaction is performed using an antigen or antibody labeled with an enzyme to a labeled substance, and a chromogenic substrate is added to measure enzyme activity.	6.0-20.0(μg/mL)	Immediately before next administration (Trough concentration)
N-Acetylprocainamide（Suspended beyond orders placed 11-30-2017）	Plasma 0.4	PH5 ↓ A00			2-4	Enzyme immunoassay(EIA) EIA (Enzyme Immunoassay Assay) Enzyme immunoassay The principle of measurement is the same as that of RIA. An antigen-antibody reaction is performed using an antigen or antibody labeled with an enzyme to a labeled substance, and a chromogenic substrate is added to measure enzyme activity.	6.0-20.0(μg/mL)	Immediately before next administration (Trough concentration)

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